anafranil for sex
anafranil drug has been used recently for sex in treating primary premature ejaculation (PE) in men, although it is not its main use and is considered an off-label treatment for premature ejaculation.
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what is Anafranil?
anafranl is a tricyclic antidepressant drug (TCAs). it is the choloro derivative of the chemical compound imipramine. which is a serotonin and norepinephrine reuptake inhibitor, increasing the levels of two hormones in the body, hence improving their work in the body.
norepinephrine hormone helps modulate your emotions and relieve emotional stress enhancing attention. while serotonin is the happiness hormone, it enhances your mode, appetite and your psychological status in general.
tricyclic antidepressants may also affect other hormones like such as acetylcholine and histamine.
Anafranil for sex
Anafranil which is known by its generic name clomipramine is a tricyclic antidepressant drug that is used for treating obsessive-compulsive disorder (OCD). it is used in order to relieve repetitive thoughts and behaviors and depression. and also other psychological disorders. It is also used to treat primary premature ejaculation in certain cases.
anafranil for sex has proven efficacy
Anafranil is only used for people who have primary premature ejagulation. (who already has a problem) to increase the latency of masturbation from approximately 1 min to more than 3,5 min on average.
This was shown in a study that was made on twenty-three premature ejaculators (PEs) and 11 control (healthy) subjects. They were administered 25 mg of clomipramine in a double-blind crossover design study.
So to sum up, anafranil can be used to make you last longer in bed if you have problems with ejaculation and premature masturbation. but not to make you last more than normal. as it cannot be used in erectile dysfunction and impotence.
anafranil for sex regulation
anafranil is a tricyclic antidepressant that does not cause dependence or abuse, unlike other psychiatric drugs like benzodiazepines and other opioids and amphetamines which cause ‘’high’’ feelings and recreation.
so, anafranil is a safe drug prescribed by your doctor for OCD, depression or other psychiatric use besides sexual use ofcourse.
on-demand use
a blind cross-section study published in PubMed To investigate the degree of ejaculation delay induced by on-demand treatment with 20 mg paroxetine and 25 mg clomipramine. and to notice the side effects of both drugs on the day of administration and the day after it.
the study revealed the efficacy of anafranil in treating erectile dysfunction and increasing the latency of ejaculation with an Intravaginal ejaculation latency time (IELT) of less than 1 minute.
while paroxetine had no effect if whatsoever on ejaculation
both drugs had non-sexual mild but disturbing side effects.
regular use
anafranil for sex regular dose is mostly decided by your doctor and usually taken at bedtime to prevent mild drowsiness during the day and reduce the symptoms.
anafranil for sex ‘s half-life
anafranil for sex has a long half-life, which is up to 32 hours for a 150 gm dose with a 69 hours average. a high dose of anafranil which exceeds more than 200mg side effects of the drug are more likely to show up, especially the high risk of seizures.
in addition, anafranil is not a fat-soluble drug, so its adsorption is not affected by food mostly.
it may take up to 4 weeks before you start to feel relief from your symptoms.
if you skipped a dose from anfranil, take it as soon as possible, and if it is near the next dose don’t take it.
drugs that may affect anfranil
some drugs may slow down or reduce anafranil concentration in blood and hence decrease or stop its action. for example, some drugs affect you liver enzymes accelerating the metabolism of the drug like: barbiturates, cimetidine, flecainide, fluoxetine, fluvoxamine, methylphenidate, paroxetine, phenothiazines, propafenone, quinidine, sertraline.
anafranil for sex to restore sexual function
besides its use to prevent premature ejaculation, anafranil has proven to help increase sexual satisfaction in general. and give you more confidence in bed.Clomipramine also inhibits nocturnal penile tumescence in men.
anafranil for sex use by women
studies showed that women who take anafranil as a tricyclic antidepressant drug for anixity experience low sex drive and maybe difficulty reaching climax. so it is not recommended for women to use in sex due to its side effects.
anafranil common side effects
feeling dizzy, drowsy, tired, or stressed.
tremors, jerking or uncoordinated muscle movements.
mild common side effects:
excessive sweat production.
alteration in appetite or weight.
urination problems.
vision problems.
decreased sex drive, impotence, or difficulty having an orgasm.
:anafranil for sex Serious side effects includes
– felt panicked
– suffered from skin rashes,
– had severe headache,
– lost coordination,
– had skin rashes,
– faced vomiting or severe diarrhea,
– felt agitated or iiratable,
– had a seizure or fast heart rate.
precautions before using anafranil
– don’t use anafranil with any other drug of same class TCAs
– don’t take anafranil with other drugs like taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) for at least 14 days.
– tell your doctor if you take any serotonin reuptake inhibitors like citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, and sertraline (Zoloft), trazodone, or vilazodone.
– avoid the consumption of alcohol and tobacco with anafranil as it may cause serious side effects.
– do not take anafranil if you have recently experienced a heart attack.
– avoid taking grapefruit juice or fruit during the use of anafranil, as it increases the level of them in your body and delays their actions, besides causing serious adverse effects.
– avoid having cranberry juice with anafranil for the same reason.
people who should not take anafranil
people with certain conditions shouldn’t take anfranil:
neuroblastoma
pheochromocytoma
overactive thyroid gland
manic-depression
suicidal thoughts
alcoholism
serotonin syndrome, a type of disorder with high serotonin levels
closed angle glaucoma
heart attack within the last 30 days
an atrioventricular conduction defect in the heart
prolonged QT interval on EKG
finally, you should always consult your doctor about the medications you usually use, and report immediately any side effects or allergies you may experience from anafranil, and do check or ask about the suitable dose of anafranil for sex.
written by: D.Ghadah Algohary
References:
https://pubmed.ncbi.nlm.nih.gov/8808861/
https://www.drugs.com/food-interactions/clomipramine.html